Oxidative Stress
Role of H2O2
Oxidative Stress: H2O2 Overload
DNA Damage by ·OH
Protein Peroxidation by ·OHLipid Peroxidation by ·OH
What else happens?
What we are looking for…

Oxidative Stress: H2O2 Overload
When the [H2O2] exceeds the capacity of Catalase and Gulathione peroxidase, it can be reduced to form ·OH
The hydroxyl radical is highly reactive and can lead to:
DNA Degradation
Protein Peroxidation
Lipid Peroxidation