What is proteomics?
Introduction
Fact
Proteomics and the proteome
Advantages of proteomics
Biomarkers
Existing biomarkers
Sample Preparation
Other techniques
Mass Spectrometry
How is a mass spectrometer used?
How does a mass spectrometer work?
Mass spectrometry and Proteomics
Sample Analysis
Bioinformatics
ProteinLynx Global server (PLGS)
Bioinformatics
Biomarker discovery pipeline
Potential biomarker

Mass spectrometry and Proteomics
Large macromolecules like proteins and peptides were traditionally very difficult to vaporise.
Many traditional ionisation techniques lead to unpredictable fragmentation of analytes, complicating identification.
The advent of Electrospray ionisation (ESI) and matrix assisted laser desorption ionisation (MALDI) allowed for the gentle vaporisation and ionisation of large biomolecules.